Product ID:ACRIFLAVINE HYDROCHLORIDE, A8251
MSDS Date:01/01/1999
FSC:6505
NIIN:00N092619
Status Code:A
MSDS Number: CJTRH

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

ACRIFLAVINE HYDROCHLORIDE

CAS: 8063-24-9

RTECS: AR9660000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: HARMFUL IF SWALLOWED,
INHALED OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY
TRACT. CHRONIC EFFECTS: CARCINOG EN. MAY ALTER GENETIC MATERIAL. TO
THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS DATA AND SYNONYMS SUPPLIED ARE FOR A CLOSELY RELATED
COMPOUND.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IN CASE OF CONTACT,
IMMEDIATELY FLUSH SKIN WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST
15 M INUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES.
INHALATION: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
REUSE.

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT TO PREVENT CONTACT WITH SKIN AND EYES.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE. SWEEP
UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING
DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS
COMPLETE. AVOID INHALATION.

Handling and Storage Precautions:KEEP TIGHTLY CLOSED. STORE IN A COOL,
DRY PLACE.
Other Precautions:DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON
CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. WASH THOROUGHLY
AFTER HANDLING. IRRITANT. CARCINOGEN. MUTAGEN.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED CHEMICAL
RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health

Melt/Freeze Pt:=260.C, 500.F
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY PRODUCE
CARBON MONOXIDE, CARBON DIOXIDE AND NITROGEN OXIDES. HYDROGEN
CHLORIDE GAS.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS #: AR9660000 ACRIDINUM,
3,6-DIAMINO-10-METHYL-, CHLORIDE MIXED WITH 3,6-ACRIDINEDIAMINE.
TARGET ORGAN DATA: TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY
RTECS CRITERIA). TUMORIGENIC (TUMORS AT SI TE OF APPLICATION). ONLY
SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
INFORMATION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:EUROPEAN INFORMATION - CAUTION:
SUBSTANCE NOT YET FULLY TESTED. TOXIC. R 45 MAY CAUSE CANCER. R 46
MAY CAUSE HERITABLE GENETIC DAMAGE. R 36/37/38 IRRITATING TO EYES,
RESPIRATORY SYSTEM AND SKIN. S 45 IN CASE OF ACCIDENT OR IF YOU
FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE
POSSIBLE). S 26 IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY
WITH PLENTY OF WATER AND SEEK MEDICAL A DVICE. S 36/37/39 WEAR
SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. S 22
DO NOT BRE ATHE DUST. RTECS DATA AND SYNONYMS SUPPLIED ARE FOR A
CLOSELY RELATED COMPOUND. (STATE REG INFO)
State Regulatory Information:N/P. REVIEWS, STANDARDS AND REGULATIONS.
OEL=MAK. IARC CANCER REVIEW:ANIMAL INADEQUATE EVIDENCE IMEMDT
13,31,1977. IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA IMEMDT
13,31,1977. IARC CANCER REVIEW:GROUP 3 IMSUDL 7,56,1987. NOES
1983: HZD X1531; NIS 1; TNF 10; NOS 1; TNE 40; TFE 10. EPA GENETOX
PROGRAM 1988, POSITIVE: ASPERGILLUS-FORWARD MUTATION. EPA GENETOX
PROGRAM 1988, POSITIVE: SPERM MORPHOLOGY- MOUSE; S
CEREVISIAE-HOMOZYGOSIS. EPA GENETOX PROGRAM 1988, NEGATIVE: IN VIVO
CYTOGENETICS-MAMMALIAN OOCYTE; HOSE-MEDIATED ASSAY. EPA GENETOX
PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS; S CEREVISIAE
GENE CONVERSION.